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• Bacteria-based cancer therapy, also known as Bug Drugs, leverages the distinctive properties of certain bacteria to detect, target, and destroy cancer cells.
• These therapies take advantage of the unique ability of certain bacteria to proliferate inside tumours. 
• The low oxygen, acidic and dead tissue in the area around the cancer – the tumour “microenvironment”, create an ideal niche for some bacteria to thrive. 
• Once there, bacteria can, in theory, directly kill tumour cells or activate the body’s immune responses against the cancer. 

• However, introducing live bacteria into a patient’s body can cause harm. Researchers have had to carefully attenuate (weaken) bacterial strains to ensure they don’t damage healthy tissue. 
• Additionally, controlling the bacteria’s behaviour within the tumour and preventing them from spreading to other parts of the body has been difficult.